The Blazers (8-5) fell behind the Shockers (7-4) early and trailed by as many as sixteen points in the second-half before Vaden led a UAB charge.
Coming off a 33-point game at Kentucky and second nationally in three-pointers made entering Saturday, Vaden scored 12 points in a 15-2 run that cut Wichita State's lead to 51-48 with 4:35 to play.
Vaden's final six points came on deep, contested threes. But his hot hand was not in the game much longer as he fouled out with 3:12 remaining in the contest.
He finished 5-of-13 from the three-point line and scored 14 points in the second half. It was the twelfth game this season that Vaden has scored in double digits.
After Vaden fouled out, Wichita State regained momentum with two three-pointers that built its lead to nine with just over a minute remaining, and would go on for the victory.
Phil Thomasson led the Shockers with 15 points and seven rebounds.
The game started off with both teams trading baskets, but a five-point possession started a key 13-0 run for Wichita State midway through the first half.
The Shockers' J.T. Durley hit a 12-foot jump shot while being fouled. He missed the free throw, but Wichita State recovered the rebound and worked the ball to Braeuer, who rattled in a three-pointer. Durley would hit another three shortly after that put the Shockers up by 10.
UAB made seven shots and had 10 turnovers in the first half, but out shot and out scored the Shockers in the second half.
Frank Holmes led the Blazers with nine rebounds and chipped in six points. Tip-off was delayed by an hour due to weather-related issues.
The Blazers return to the court on Dec. 29 for a home game against Old Dominion. Tip-off is schedule for 7 p.m. in Bartow Arena.